Therapeutic compositions for the treatment of a respiratory...

A - Human Necessities – 61 – K

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A61K 38/46 (2006.01) A61K 31/00 (2006.01) A61K 33/00 (2006.01) A61K 33/06 (2006.01) A61K 33/14 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2443107

The equilibrium between G actin and F actin is shifted towards the F actin confirmation with compounds such as the ionic form of magnesium or potassium. The higher amount of F actin decreases the inhibition of nucleases such as DNAse I by monomeric G actin. The increased performance of the nuclease results in better treatment of patients suffering from cystic fibrosis or other diseases associated with viscous mucus.

L'invention concerne l'actine G et l'actine F dont l'équilibre est remplacé par l'affirmation de l'actine F grâce à des composés tels que la forme ionique du magnésium ou du potassium. La quantité supérieure d'actine réduit l'inhibition des nucléases telles que la DNAse I par l'actine G monomérique. L'efficacité améliorée de la nucléase permet de mieux traiter les patients souffrant de fibrose cystique ou d'autres maladies associées au mucus visqueux.

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