C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C12N 15/00 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2368379
The present invention relates to human protein kinase B .gamma. polypeptides and to nucleic acid molecules coding for such polypeptides. The invention further relates to vectors and cells comprising said nucleic acid molecules, as well as to methods for screening test compounds which affect the insulin signaling pathway. In contrast to the previously known protein kinase B .gamma. from rat brain, the human protein kinase B .gamma. polypeptides comprise two activating phosphorylation residues; Thr305 and Ser472.
Cette invention se rapporte à des polypeptides de protéine-kinase B.gamma. humaine et à des molécules d'acide nucléique codant ces polypeptides. Cette invention se rapporte en outre à des vecteurs et à des cellules comprenant ces molécules d'acide nucléique, ainsi qu'à des procédés de criblage de composés de test qui modifient le canal de signalisation de l'insuline. A la différence de la protéine-kinase B.gamma. connue jusqu'à présent, qui est tirée de la cervelle du rat, les polypeptides de protéine-kinase B.gamma. humaine contiennent deux résidus de phosphorylation activateurs, Thr?305¿ et Ser?472¿.
Biovitrum Ab
Gowling Lafleur Henderson Llp
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