C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2501552
This invention is directed towards substituted aminoquinuclidine compounds of Formula (I); (I) wherein: Ar is selected from the group consisting of aryl and heteroaryl; n is an integer from 0 to 2; useful as delta-opioid receptor modulators, delta-opioid receptor agonists useful as analgesics and delta- opioid receptor antagonists useful as immunosuppressants, antiinflammatory agents, agents for the treatment of neurological and psychiatric conditions, medicaments for drug and alcohol abuse, agents for treating gastritis and diarrhea, cardiovascular agents and agents for the treatment of respiratory diseases.
L'invention concerne des composés d'aminoquinuclidine de substitution utiles en tant que modulateurs du récepteur delta-opioïde, des agonistes du récepteur delta-opioïde utiles en tant qu'analgésiques, et des agonistes du récepteur delta-opioïde utiles en tant qu'immunosuppresseurs, des agents anti-inflammatoires, des agents pour le traitement de troubles neurologiques et psychiatriques, des médicaments contre l'abus de drogues et d'alcool, des agents pour traiter une gastrite et une diarrhée, des agents cardio-vasculaires et des agents pour le traitement de maladies respiratoires.
Boyd Robert E.
Reitz Allen B.
Janssen Pharmaceutica N.v.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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