Methods for treating sepsis

Details Methods for treating sepsis Methods for treating sepsis

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 38/17 (2006.01) A61P 7/02 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2347250

The present invention provides a method of treatment for patients with sepsis. The claimed treatment is a combination therapy with protein C and BPI protein. Combining protein C, with its anti-coagulant/anti-inflammatory properties, and BPI, with its bactericidal and endotoxin neutralizing activities, provides an effective, synergistic therapy for sepsis that will reduce or ameliorate the adverse events and improve the clinical outcome of septic patients.

L'invention concerne une méthode de traitement de patients présentant une septicémie. La méthode revendiquée est une thérapie combinant la protéine C et la protéine BPI (protéine bactéricide augmentant la perméabilité). La combinaison de la protéine C, aux propriétés anticoagulantes/anti-inflammatoires, à la protéine BPI, qui possède des activités bactéricide et de neutralisation d'endotoxines, permet d'obtenir une thérapie synergique efficace contre la septicémie, qui réduit ou atténue les effets nuisibles de l'infection et améliore les résultats cliniques de patients atteints de septicémie.

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