Trisubstituted pyrazoles as acetylcholine receptor modulators

Details Trisubstituted pyrazoles as acetylcholine receptor modulators Trisubstituted pyrazoles as acetylcholine receptor modulators

C - Chemistry, Metallurgy

07

D

C07D 231/38 (2006.01) A61K 31/455 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 407/04 (2006.01) C07D 407/14 (2006.01)

Patent

CA 2722805

The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to Formu-la (I). The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive al-losteric modulator having the capability to increase the efficacy of nicotinic receptor agonists.

La présente invention concerne des dérivés 1-alkyl-3-anilino-5-aryl-pyrazoles et leurs sels pharmaceutiquement acceptables, des procédés pour les préparer, des compositions pharmaceutiques les contenant, et leur utilisation en thérapeutique, ces dérivés étant représentés par la formule (I). L'invention concerne en particulier des modulateurs allostériques positifs des récepteurs nicotiniques de l'acétylcholine, ces modulateurs allostériques positifs ayant la capacité d'augmenter l'efficacité des agonistes des récepteurs nicotiniques.

Affiliated with

Also associated with

Rating

Trisubstituted pyrazoles as acetylcholine receptor modulators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Trisubstituted pyrazoles as acetylcholine receptor modulators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Trisubstituted pyrazoles as acetylcholine receptor modulators will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1422219