Manufacturing dissolvable dosage forms

Details Manufacturing dissolvable dosage forms Manufacturing dissolvable dosage forms

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61J 3/00 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/70 (2006.01) A61J 3/06 (2006.01) A61J 3/07 (2006.01)

Patent

CA 2440770

A method of manufacturing a dosage form is described wherein a liquid solution of a biologically compatible polymer containing a suspension of particulate material that is insoluble in the polymer is supplied to a liquid supply tube (2) having an outlet (2a) and an electrical field is established between the outlet (2a) and a surface (19) spaced from the outlet (2a) to cause liquid issuing from the outlet to form a jet which dries to form a polymer fibre containing particles of the particulate material and which deposits onto the surface (19) to form a dosage which consists of said particulate containing fibre which fibre dissolves or disintegrates in a wet environment such as the mouth.

La présente invention concerne un procédé de fabrication d'une dose posologique. En l'occurrence, une solution liquide d'un polymère biocompatible contenant une matière particulaire en suspension, la solution étant insoluble dans le polymère, est fournie à un tube d'alimentation de liquide (2) comportant un orifice de sortie (2a). On établit un champ électrique entre l'orifice de sortie (2a) et une surface éloignée de l'orifice (2a) de façon que le liquide sortant de l'orifice vienne former un jet qui, en séchant, forme une fibre polymère contenant des particules de la matière particulaire, puis se dépose sur la surface (19) de façon à former une dose posologique constituée de ladite fibre contenant la matière particulaire se dissolvant ou se désintégrant en environnement humide, notamment dans la bouche.

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