Novel benzo-fused heterocycles as endothelin antagonists

Details Novel benzo-fused heterocycles as endothelin antagonists Novel benzo-fused heterocycles as endothelin antagonists

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/472 (2006.01) A61K 31/513 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01) A61K 31/553 (2006.01) A61P 19/00 (2006.01) C07D 217/16 (2006.01) C07D 223/16 (2006.01) C07D 243/24 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01) C07D 413/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2454417

The invention relates to novel benzo-fused heterocycles of structure (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists. Formula (I)

L'invention concerne des hétérocycles à fusion benzo, de structure (I), et leur utilisation comme principes actifs dans l'élaboration de compositions pharmaceutiques. L'invention concerne en outre certains aspects connexes, y compris des procédés pour l'élaboration de composés et de compositions pharmaceutiques renfermant un ou plusieurs de ces composés, et en particulier leur utilisation en tant qu'antagonistes vis-à-vis de récepteurs de l'endothéline.

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