Therapeutic compounds: pyridine as scaffold

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 213/81 (2006.01) A61K 31/44 (2006.01) A61K 31/4965 (2006.01) C07D 241/24 (2006.01)

Patent

CA 2565065

Compounds of formulas I, IA, and IB or IC or pharmaceutically acceptable salts thereof: wherein A, A1, A2, A3, A4, R2, R3, R4 and n are as defined in the specifications well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

L'invention porte sur la préparation de composés des formules I, IA, et IB ou IC ou de sels pharmaceutiquement acceptables de ces derniers, où A, A?1¿, A?2¿, A?3¿, A?4¿, R?2¿, R?3¿, R?4¿ et n sont tels que définis dans les spécifications, et de sels et de compositions pharmaceutiques comprenant les composés précités. Les composés de l'invention sont utilisés en thérapie, en particulier dans le soulagement de la douleur.

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