Antidepressant azaheterocyclylmethyl derivatives of...

C - Chemistry – Metallurgy – 07 – D

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C07D 491/04 (2006.01) A61K 31/47 (2006.01) C07D 221/00 (2006.01) C07D 319/00 (2006.01)

Patent

CA 2498134

Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

L'invention concerne des composés représentés par la formule générale (I) qui sont utiles pour le traitement de la dépression (y compris, sans en exclure d'autres, du trouble dépressif majeur, de la dépression enfantine et de la dysthymie), de l'anxiété, du trouble panique, de l'état de stress post-traumatique, du trouble dysphorique prémenstruel (également désigné sous le nom de syndrome prémenstruel), du trouble déficitaire de l'attention (avec et sans hyperactivité), du trouble obsessionnel-compulsif, du trouble d'anxiété sociale, du trouble d'anxiété généralisée, de l'obésité, des troubles de l'alimentation, tels que l'anorexie mentale et la boulimie, des bouffées vasomotrices, de la cocaïnomanie et de l'alcoolisme, de la dysfonction sexuelle et de maladies associées.

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