Anti-myosin va sirna and skin depigmentation

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A61K 8/60 (2006.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 17/00 (2006.01) A61Q 19/02 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2632837

The present invention relates to novel isolated siRNAs comprising a sense RNA strand and a complementary antisense RNA strand which together form an RNA duplex, characterized in that the sense RNA strand comprises a sequence which has at most one nucleotide that is distinct in relation to a fragment of 14 to 30 contiguous nucleotides of the nucleotide sequence of exon F of the gene encoding the myosin Va protein, and also to compositions comprising at least one such siRNA, and to the use of at least one such siRNA as a cosmetic or therapeutic agent for skin depigmentation.

La présente invention concerne de nouveaux siRNA isolés comprenant un brin d'ARN sens et un brin d'ARN antisens complémentaire formant ensemble un duplex d'ARN, caractérisé en ce que le brin d'ARN sens comprend une séquence qui possède au plus un nucléotide distinct par rapport à un fragment de 14 à 30 nucléotides contigus de la séquence nucléotidique de l'exon F du gène codant pour la protéine myosine Va, ainsi que des compositions comprenant au moins un tel siRNA, et l'utilisation d'au moins un tel siRNA comme agent cosmétique ou thérapeutique pour la dépigmentation de la peau.

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