Therapeutic monoclonal anti-tirc7 antibodies for use in...

Details Therapeutic monoclonal anti-tirc7 antibodies for use in... Therapeutic monoclonal anti-tirc7 antibodies for use in...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) C07H 21/00 (2006.01) C07K 7/08 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2486689

Provided are specific antibodies against T-cell immune response cDNA7 (TIRC7) costimulatory molecule, which are capable of inhibiting proliferation of peripheral blood mononuclear cells (PBMCs). In particular, high affinity monoclonal and chimeric anti~TIRC7 antibodies are described. Compositions comprising such antibodies and their use for the treatment of immune diseases are provided.

L'invention porte sur des anticorps spécifiques contre une molécule co-stimulatrice de l'ADNc7 (TIRC7) d'une réponse immune des lymphocytes T, ces anticorps étant capables d'inhiber la prolifération des cellules mononucléaires du sang périphérique. L'invention porte également sur des anticorps anti-TIRC7 monoclonaux et chimères de haute affinité, et sur des compositions comprenant ces anticorps et leur utilisation dans le traitement des maladies immunes.

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