Process for preparation of 1,3-benzodioxole-2-spiro-...

C - Chemistry – Metallurgy – 07 – D

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C07D 317/72 (2006.01) A61K 31/357 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 9/02 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 11/02 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07C 51/377 (2006.01) C07C 65/03 (2006.01) C07C 65/21 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2491464

A process for the preparation of 1,3-benzodioxole-2- spirocycloalkane derivatives represented by the general formula (VII), characterized by adding a base to a mixture comprising a compound represented by the general formula (V) and a compound represented by the general formula (VI) to thereby make the compound (V) react with the compound (VI): (A) wherein R1 is hydroxyl or substituted or unsubstituted lower alkoxy; R2 is an aromatic heterocyclic group or the like; Y is lower alkyl or the like; and n is an integer of 1 to 6.

L'invention concerne une méthode de préparation de dérivés de 1,3-benzodioxole-2-spiro-cycloalcane de formule générale (VII), caractérisés par l'adjonction d'une base à un mélange contenant un composé de formule générale (V) et un composé de formule générale (VI), pour obtenir une réaction du composé (V) avec le composé (VI). Dans ladite formule, R?1¿ est hydroxyle ou alcoxy inférieur substitué ou insubstitué; R?2¿ est un groupe hétérocyclique aromatique ou analogue; Y est alkyle inférieur ou analogue; et n est un entier compris entre 1 et 6.

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