A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/155 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/5415 (2006.01) A61K 45/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C07C 279/26 (2006.01) C07D 239/48 (2006.01) C07D 239/95 (2006.01) C07D 403/10 (2006.01) C07D 471/04 (2006.01) C07D 475/08 (2006.01) C07D 487/04 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2373992
Novel medicinal compositions containing anti-Fas antibody which are useful as preventives or remedies for autoimmune diseases or rheumatoid arthritis. More particularly, medicinal compositions containing as the active ingredients antihuman Fas antibody having an activity of inducing apoptosis and a compound having an antagonism to folic acid or an effect of inhibiting dihydrofolate reductase. By using these medicinal compositions, the content of anti-Fas antibody can be reduced in preventives or remedies for autoimmune diseases or rheumatoid arthritis containing anti-Fas antibody. Thus, the possibility of the appearance of the tolerance in the patient's body due to the expression of an antibody against the anti-Fas antibody, etc., which makes it possible to provide excellent preventives or remedies usable in long-term administration.
L'invention concerne des nouvelles compositions médicinales contenant un anticorps anti-Fas et utiles en thérapie préventive ou curative de maladies auto-immunes ou de la polyarthrite rhumatoïde. Ces compositions médicinales contiennent notamment, en tant que principes actifs, l'anticorps dirigé contre Fas humain, et possédant une activité d'induction de l'apoptose, ainsi qu'un composé antagoniste de l'acide folique ou possédant un effet inhibiteur de la dihydrofolate réductase. En utilisant ces compositions médicinales, on peut réduire la teneur en anticorps anti-Fas présente dans les médicaments préventifs ou curatifs des maladies auto-immunes ou de la polyarthrite rhumatoïde. Ainsi, il existe une possibilité d'apparence d'un état de tolérance, dans le corps d'un patient, dû à l'expression d'un anticorps dirigé contre l'anticorps anti-Fas, etc., ce qui rend possible la préparation d'excellents médicaments préventifs ou curatifs, et leur utilisation dans une administration à long terme.
Ichikawa Kimihisa
Serizawa Nobufusa
Yoshida Hiroko
Marks & Clerk
Sankyo Company Limited
LandOfFree
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