Pyrimidine-2, 4, 6-trione metallo-proteinase inhibitors

Details Pyrimidine-2, 4, 6-trione metallo-proteinase inhibitors Pyrimidine-2, 4, 6-trione metallo-proteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/515 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2483500

The present invention relates to N-substituted-heteroaryloxy-aryloxy-2, 4, 6- trione metalloproteinase inhibitors of the formula (I) wherein X, A, Y, B, G and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders. The compounds are matrix metalloproteinase (MMP) inhibitors.

L'invention concerne des inhibiteurs de métalloprotéinase à base d'hétéroaryloxy-aryloxy-2, 4, 6-trione N substituée de formule (I) dans laquelle X, A, Y, B, G et R?1¿ sont définis dans la description, ainsi que des compositions pharmaceutiques et des méthodes de traitement de l'inflammation, du cancer et d'autres troubles. Les composés sont des inhibiteurs de la métalloprotéinase de matrice (MMP).

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