Novel t-cell lymphoma cdna clones

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 39/00 (2006.01) C07K 14/46 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01)

Patent

CA 2080018

The present invention provides novel DNA sequences, recombinant DNA (rDNA) molecules, processes for producing novel T-cell proteins expressed in T-cell development, the novel T-cell proteins in substantially pure farm and antibodies which bind to the novel proteins. More particularly, it relates to novel DNA sequences expressed in appropriate host and the novel T- cell proteins produced in these hosts. The present invention also provides novel transmembrane proteins in substantially pure form, rDNA molecules encoding said transmembrane proteins and processes for producing the novel transmembrane proteins. The DNA sequences and recombinant DNA molecules of this invention are characterized in that they are expressed by T lym- phoma cells and have at least one of the following characteristics: (1) is expressed in normal thymus, activated spleen cells, ar gut associated lymphoid tissue. (2) is expressed in ovarian tissue, normal liver and/or in a stage specific manner in embryonic devel- opment and (3) encode novel transmembrane proteins having multiple membrane spanning domains.

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