Thiazole derivatives having vap-1 inhibitory activity

Details Thiazole derivatives having vap-1 inhibitory activity Thiazole derivatives having vap-1 inhibitory activity

C - Chemistry, Metallurgy

07

D

C07D 277/46 (2006.01) A61K 31/426 (2006.01)

Patent

CA 2575411

A compound of the formula (I), (II), (III) or (IV): wherein each symbol is as defined in the specification,or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.

L'invention concerne un composé de formule (I), (II), (III) ou (IV), dans lesquelles chaque symbole est spécifié dans la description, ou un de ses sels pharmaceutiquement acceptables, utilisés en tant qu'inhibiteur (VAP-1) de la protéine 1 d'adhésion vasculaire, une composition pharmaceutique, et un procédé pour prévenir ou traiter une maladie associée à la VAP-1, en particulier un oedème maculaire. Ledit procédé comprend l'administration d'une quantité efficace du composé ou d'un de ses sels pharmaceutiquement acceptable à un sujet, et analogues.

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