A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/167 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2463552
The present application is directed to a method of inhibiting HDAC in the brain of a mammal. The method comprises administering to a mammal a HDAC inhibiting amount of a histone deacetylase inhibitor compound. The present application is further directed to a method of treating diseases of the central nervous system (CNS) comprising administering to a individual in need of treatment a therapeutically effective amount of an inhibitor of HDAC. In particular embodiments, the CNS disease is a neurodegenerative disease. In further embodiments, the neurogenerative disease is an inherited neurodegenerative disease, such as those inherited neurodegenerative diseases which are polyglutamine expansion diseases. In other embodiments, the disorder is cancer of the brain. The individual is a mammal, such as a primate or human.
L'invention se rapporte à un procédé d'inhibition de HDAC dans le cerveau d'un mammifère. Le procédé consiste à administrer chez un mammifère une quantité inhibitrice de HDAC d'un composé inhibiteur d'histone-déacétylase. Cette application concerne aussi un procédé de traitement de maladies du système nerveux central (SNC) consistant à administrer à un individu nécessitant un traitement une quantité thérapeutiquement efficace d'un inhibiteur de HDAC. Dans certains modes de réalisation particuliers selon l'invention, la maladie du SNC est une maladie dégénérative. Dans d'autres modes de réalisation selon l'invention, la maladie neurodégénérative est une maladie neurodégénérative héréditaire telles que ces maladies neurodégénératives héréditaires qui sont des maladies à expansion de polyglutamine. Dans d'autres modes de réalisation, ce trouble se traduit par un cancer du cerveau. L'individu est un mammifère tel qu'un primate ou un humain.
Marks Paul A.
Richon Victoria M.
Rifkind Richard A.
Ridout & Maybee Llp
Sloan-Kettering Institute For Cancer Research
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