Non-nucleoside reverse transcriptase inhibitors

Details Non-nucleoside reverse transcriptase inhibitors Non-nucleoside reverse transcriptase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/40 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/55 (2006.01) A61P 31/18 (2006.01) C07D 207/36 (2006.01) C07D 403/06 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2665007

Compounds of Formula (I) are HIV reverse transcriptase inhibitors, wherein X, R1, R2, R3, R4 and R5 are defined herein. The compounds of Formula (I) and their pharmaceutically acceptable salts are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

L'invention concerne des compositions de formule (I) qui sont des inhibiteurs de la transcriptase inverse du VIH, où X, R1, R2, R3, R4 et R5 sont définis dans le présent document. Les composés de formule (I) et leurs sels pharmaceutiquement acceptable sont utiles dans l'inhibition de la transcriptase inverse du VIH, la prophylaxie et le traitement de l'infection par VIH et dans la prophylaxie, le retardement du début ou de la progression, et le traitement du SIDA. Les composés et leurs sels peuvent être employés en tant qu'ingrédients dans des compositions pharmaceutiques, éventuellement en combinaison avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins.

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