C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 473/00 (2006.01) A61K 31/155 (2006.01) A61K 31/4375 (2006.01) A61K 31/52 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2631737
The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-4 enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-4 enzyme is involved.
La présente invention concerne des amino-pipéridines substituées et fusionnées innovantes de formule structurelle (I) qui agissent en tant qu'inhibiteurs de l'enzyme dipeptidyl peptidase-4 et qui sont utilisables pour la prévention ou le traitement de maladies dans lesquelles l'enzyme dipeptidyl peptidase-4 est impliquée, par exemple le diabète et en particulier le diabète de type 2. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation desdits composés et compositions pour la prévention ou le traitement de maladies dans lesquelles l'enzyme dipeptidyl peptidase-4 est impliquée. Formule (I) :
Cox Jason M.
Edmondson Scott D.
Mastracchio Anthony
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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