Methods, compositions and articles of manufacture for...

A - Human Necessities – 61 – K

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Details

A61K 33/04 (2006.01) A01N 1/00 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2605631

The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.

L'invention concerne l'utilisation d'antagonsites de l'oxygène et d'autres composés actifs permettant d'induire in vivo une stase ou une pré-stase dans des cellules, des tissus, des organes et des organismes afin d'améliorer leur capacité de survie. L'invention concerne également des compositions, des procédés, des articles manufacturés et des appareils permettant d'améliorer la capacité de survie et d'effectuer une stase ou une pré-stase dans l'un quelconque de ces matériaux biologiques afin de les préserver et/ou de les protéger. Dans des modes de réalisation spécifiques, l'invention concerne également des méthodes thérapeutiques et des appareils utilisant lesdits composés actifs dans le cas d'une transplantation d'organe, d'une hyperthermie, de la cicatrisation de lésions, d'un choc hémorragique, d'une cardioplégie par chirurgie de pontage coronarien, d'une neurodégénération, d'une hypothermie et d'un cancer.

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