Mitochondria-targeted anti-tumour agents

Details Mitochondria-targeted anti-tumour agents Mitochondria-targeted anti-tumour agents

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 19/00 (2006.01) C07K 14/435 (2006.01)

Patent

CA 2699794

Described are mitochondria-targeted anti-tumor agents, and methods of making and using the same for the treatment of disorders associated with unwanted cell proliferation. In one aspect, the invention provides compositions having the formula: A-B, wherein A is a molecular chaperone inhibitor and B is a mitochondria-penetrating moiety and A and B are linked, optionally by a linking moiety; and pharmaceutically acceptable salts.

La présente invention concerne des agents antitumoraux ciblant les mitochondries, ainsi que des procédés de production et d'utilisation desdits agents pour le traitement de troubles associés à une prolifération cellulaire indésirable.

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