C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/04 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2474916
The detection of mutations in fecal DNA represents a promising, non-invasive approach for detecting colorectal cancers in average risk populations. One of the first practical applications of this technology involves the examination of microsatellite markers to sporadic cancers with mismatch repair deficiencies. As such cancers nearly always occur in the proximal colon, this test is useful as an adjunct to sigmoidoscopy, which detects only distal colorectal lesions.
La détection de mutations dans l'ADN fécal représente une approche prometteuse non invasive pour la détection de cancers colorectaux dans des populations à risque moyen. Une des premières applications pratiques de cette technologie concerne l'examen de marqueurs microsatellites sur des cancers sporadiques ayant des déficiences de réparation des mésappariements. Etant donné que ces cancers surviennent à proximité du colon, ce test sert d'allié à la sigmoïdoscopie, qui détecte uniquement les lésions colorectales distales.
Kinzler Kenneth W.
Traverso C. Giovanni
Vogelstein Bert
The Johns Hopkins University School Of Medicine
Torys Llp
LandOfFree
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