C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/44 (2006.01) C12Q 1/18 (2006.01) C12Q 1/26 (2006.01) C12Q 1/533 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2238283
This invention provides a method to identify compounds potentially useful for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia. Such compounds are useful for pharmaceutical compositions and uses for treating neoplasia.
Pamukcu Rifat
Piazza Gary A.
Thompson W. Joseph
Cassan Maclean
Cell Pathways Inc.
Osi Pharmaceuticals Inc.
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