Short peptides for treatment of neurological degenerative...

Details Short peptides for treatment of neurological degenerative... Short peptides for treatment of neurological degenerative...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/04 (2006.01) C07K 5/00 (2006.01) C07K 14/52 (2006.01)

Patent

CA 2327811

The HIV-1 envelope protein gpl20 is toxic to rodent and human neurons by indirect mechanisms requiring accessory glial cells. Chemokines are known to block gpl20 interactions with chemokine receptors on T cells, macrophages, and microglia, thereby preventing viral infection. Gpl20-induced neuronal killing in rat hippocampal cultures was partially or completely prevented by specific short peptides related to chemokines, specifically KEYFTS and LESYT. These peptides thus have use in the treatment of neurological degenerative diseases having symptoms associated with neuronal cell death.

Selon cette invention, la protéine d'enveloppe gpl20 du virus VIH-1 est toxique par rapport aux neurones des rongeurs et des humains en raison de mécanismes indirects nécessitant des cellules gliales supplémentaires. On connaît des chimiokines qui bloquent les interactions gpl20 avec les récepteurs de chimiokines sur les lymphocytes T, les macrophages et les microgliocytes et empêchent ainsi l'infection virale. On a pu limiter ou même empêcher la mort de neurones dans des cultures hippocampiques chez le rat, provoquée par gpl20, au moyen de peptides courts liés aux chimiokines, et plus particulièrement de KEYFTS et de LESYT. Ces peptides peuvent être utilisés pour traiter des maladies neurdégénératives dont les symptômes sont associés à la mort de neurones.

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