Production of recombinant factor viii in the presence of...

Details Production of recombinant factor viii in the presence of... Production of recombinant factor viii in the presence of...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/755 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2175628

Recombinant Factor VIII expression in a mammalian cell culture can be increased by including a novel liposome-like substance in the culture medium. The liposome-like substance comprises at least two (preferably at least three) different lipids in defined molar ratios. In a preferred embodiment, the addition of a liposome-like substance comprised of dioleoyl phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine in a molar ratio of 4:1 :1 to the culture medium of GS-MDR cells resulted in an increase in FVIII production by a factor greater than five.

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