C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) A61P 25/06 (2006.01)
Patent
CA 2584241
Compounds of Formula I and formula II (where variables D, R2, R4, A, B, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
L'invention concerne des composés représentés par la formule (I) et la formule (II) (dans lesquelles les variables D, R2, R4, A, B, W, X, Y et Z sont telles que définies dans la spécification) utilisés comme antagonistes des récepteurs CGRP et pour traiter ou prévenir des maladies dans lesquelles le CGRP est impliqué, notamment, les maux de tête, la migraine et l'algie vasculaire de la face. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, l'utilisation desdits composés et des compositions permettant de traiter ou de prévenir les maladies dans lesquelles le CGRP est impliqué.
Burgey Christopher S.
Deng James Z.
Nguyen Diem N.
Paone Daniel V.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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