C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/71 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/66 (2006.01) G01N 33/50 (2006.01) G01N 33/66 (2006.01)
Patent
CA 2340796
Novel IRAP-BP polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length IRAP-BP polypeptides, the invention further provides isolated IRAP-BP fusion proteins, antigenic peptides and anti-IRAP-BP antibodies. The invention also provides IRAP-BP nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an IRAP-BP gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
L'invention concerne de nouveaux polypeptides, de nouvelles protéines, et de nouvelles molécules d'acides nucléiques IRAP-BP. Hormis les polypeptides IRAP-BP pleine longueur isolés, l'invention concerne également des protéines de fusion IRAP-BP isolées, des peptides antigéniques et des anticorps anti-IRAP-BP. L'invention concerne, en outre, des molécules d'acides nucléiques IRAP-BP, des vecteurs d'expression recombinés contenant une molécule d'acides nucléiques de l'invention, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, et des animaux transgéniques dans lesquels un gène IRAP-BP a été introduit ou brisé. L'invention concerne enfin des méthodes diagnostiques, thérapeutiques et de criblage utilisant les compositions de l'invention.
Lin Baozhen
Pilch Paul F.
Tojo Hideaki
Borden Ladner Gervais Llp
Trustees Of Boston University
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