Mch antagonists and their use in the treatment of obesity

Details Mch antagonists and their use in the treatment of obesity Mch antagonists and their use in the treatment of obesity

C - Chemistry, Metallurgy

07

D

C07D 211/26 (2006.01) A61K 31/445 (2006.01) A61K 45/06 (2006.01) A61P 3/04 (2006.01) C07D 211/28 (2006.01) C07D 211/34 (2006.01) C07D 211/58 (2006.01) C07D 211/96 (2006.01) C07D 211/98 (2006.01) C07D 241/04 (2006.01) C07D 295/155 (2006.01) C07D 295/215 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2441239

The present invention discloses compounds of the formula (I) which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

La présente invention concerne des composés de formule (I), qui sont de nouveaux antagonistes pour l'hormone concentrant la mélanine (MCH), ainsi que des procédés de préparation desdits composés. Dans un autre mode de réalisation, cette invention concerne des compositions pharmaceutiques renfermant lesdits antagonistes de l'hormone MCH ainsi que des procédés d'utilisation desdits antagonistes dans le traitement de l'obésité, de troubles métaboliques, de troubles alimentaires tels que l'hyperphagie et du diabète.

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