Aminoindazolylurea derivatives

Details Aminoindazolylurea derivatives Aminoindazolylurea derivatives

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/416 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2658976

Disclosed are novel aminoindazole urea derivatives of formula (I), wherein R1, R2, R3, R4, R5, X, and Y have the meanings indicated in claim 1. Said aminoindazole urea derivatives are SGK inhibitors and can be used for the treatment of SGK-related diseases and ailments such as diabetes, obesity, metabolic syndrome (dyslipidemia), systemic and pulmonary hypertension, cardiovascular diseases, and kidney diseases, more generally for any kind of fibroses and inflammatory processes.

L'invention concerne de nouveaux dérivés d'aminoindazole de la formule (I) dans laquelle R1, R2, R3, R4, R5, X et Y sont tels que définis dans la description. Ces nouveaux dérivés d'aminoindazole sont des inhibiteurs de la SGK et peuvent être utilisés pour le traitement de maladies liées à la SGK et affections comme le diabète, l'obésité, le syndrome métabolique (dyslipidémie), hypertonie généralisée et pulmonaire, maladies cardio-vasculaires et maladies rénales, et en général tout type de fibroses et processus inflammatoires.

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