Novel vitamin d analogues

Details Novel vitamin d analogues Novel vitamin d analogues

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/50 (2006.01) C07F 7/18 (2006.01) C07F 9/117 (2006.01) C07H 15/222 (2006.01)

Patent

CA 2053231

Novel compounds are provided herein which are represented by the general Formula I Image in which R stands for an alkyl group containing from 7 to 12 carbon atoms, which is substituted with at least one hydroxy group; and derivatives of such compound in which at least one of the hydroxy groups has been transformed into ~O-acyl, or ~O- glycosyl or phosphate groups, such groups being hydrolysable in vivo. Such compounds are useful for preparing pharmaceutical compositions for, and for using such pharmaceutical composition for, the treatment and/or prophylaxis of autoimmune diseases, e. g., diabetes melitis and hypertension; inflammatory diseases, e. g., rheumatoid arthritis and asthma; and diseases characterised by abnormal cell differentiation and/or cell proliferation, and/or imbalance in the immune system.

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