Methods of therapy for hiv infection

Details Methods of therapy for hiv infection Methods of therapy for hiv infection

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 31/33 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 45/06 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2425596

Methods for promoting immunologic control of human immunodeficiency virus (HIV) in an HIV-infected subject are provided. The methods comprise administering to the subject highly active antiretroviral therapy (HAART) for at least one cycle of an intermittent dosing regimen in combination with administration of a pharmaceutical composition comprising a therapeutically effective amount of interleukin-2 (IL-2) or variant thereof. The combination of daily or intermittent administration of IL-2 (or variant thereof) and intermittent HAART promotes immunologic control of viral replication in the absence of HAART, thereby prolonging the length of time a patient may discontinue HAART before viral rebound necessitates further administration of HAART. Administration of IL-2 therapy in combination with an intermittent HAART dosing regimen provides an effective method for treating a subject infected with HIV.

L'invention concerne des procédés pour le contrôle immunologique du VIH chez un sujet infecté. On engage une thérapie antirétrovirale hautement active pour au moins un cycle de posologie intermittente, en combinaison avec l'administration d'une composition pharmaceutique renfermant une quantité thérapeutiquement efficace d'interleukine-2 (IL-2) ou de variant d'IL-2. La combinaison de l'administration quotidienne ou intermittente d'IL-2 (ou de variant d'IL-2) et de la thérapie susmentionnée favorise le contrôle immunologique de la réplication virale en l'absence de thérapie considérée, ce qui prolonge la durée pendant laquelle un patient peut interrompre ladite thérapie avant que le rebond viral n'exige le lancement supplémentaire de cette thérapie. La combinaison d'administration d'IL-2 et de thérapie rétrovirale hautement active en posologie intermittente est efficace pour lutter contre l'infection par le VIH chez un sujet.

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