Clostridial toxin derivatives able to modify peripheral...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) C07K 14/33 (2006.01) C07K 14/48 (2006.01) C07K 14/52 (2006.01) C07K 14/575 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2218857

The invention relates to an agent specific for peripheral sensory afferents. The agent may inhibit the transmission of signals between a primary sensory afferent and a projection neuron by controlling the release of at least one neurotransmitter or neuromodulator from the primary sensory afferent. The agent may be used in or as a pharmaceutical for the treatment of pain, particularly chronic pain.

L'invention concerne un agent spécifique agissant sur les afférents sensoriels périphériques. L'agent peut inhiber la transmission de signaux entre un afférent sensoriel primaire et un neurone de projection en agissant sur la libération d'au moins un neurotransmetteur ou d'un neuromodulateur par l'afférent sensoriel primaire. L'agent peut être utilisé comme médicament contre les douleurs et, en particulier contre les douleurs chroniques.

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