Synthetic poly-ig receptor, receptor-antibody complexes,...

Details Synthetic poly-ig receptor, receptor-antibody complexes,... Synthetic poly-ig receptor, receptor-antibody complexes,...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/44 (2006.01) C07K 14/705 (2006.01) C07K 16/08 (2006.01) C07K 16/12 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2059289

2059289 9116061 PCTABS00007 Poly-Ig antibodies (particularly monoclonal IgA's) are complexed with a stabilizer protein derived from the poly-Ig receptor (partricularly a recombinant receptor-derived stabilizer protein), which includes at least one poly-Ig binding domain of the receptor, and substantially lacks any C-terminal transmembrane or intracellular poly-Ig receptor domains. The stabilized complex can be used as a passive vaccine administration to mucosal surfaces. Methods for in vivo screening of monoclonal poly-Ig are also disclosed. Methods of generating the complex using a monolayer of anchorage-denpendent epithelial cells engineered to make poly-Ig receptor are also disclosed. Hybridomas for manufacture of monoclonal IgA, are made by harvesting lymphoid cells from mucosal tissue (e.g. Peyer's patches) rich in such cells.

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