Controlled/modified release oral methylphenidate formulations

Details Controlled/modified release oral methylphenidate formulations Controlled/modified release oral methylphenidate formulations

A - Human Necessities

61

K

A61K 31/4458 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2355644

The invention is directed to oral modified/controlled release methylphenidate formulations which provide a rapid initial onset of effect and a prolonged duration of effect. Preferably, the peak concentration is lower than that provided by the reference standard for immediate release methylphenidate formulations, and the duration of effect falls rapidly at the end of the dosing interval so as not to affect the appetite of the patient at dinner nor the patient's sleep thereafter.

L'invention concerne des formulations orales de méthylphénidate à libération modifiée/régulée, qui assurent un déclenchement très rapide de l'effet ainsi qu'une durée prolongée de celui-ci. La concentration maximale est de préférence inférieure à celle de la norme de référence des formulations de méthylphénidate à libération immédiate, et la durée des effets baisse rapidement à la fin de l'intervalle entre deux doses successives de manière à ne pas affecter l'appétit du patient lors du dîner, ni son sommeil ensuite.

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