Soluble il-17ra/rc fusion proteins and related methods

Details Soluble il-17ra/rc fusion proteins and related methods Soluble il-17ra/rc fusion proteins and related methods

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2679588

Disclosed are antagonists of IL-17A and IL-17F. The antagonists are based on soluble IL-17RA and IL-17RC fusion proteins, including hybrid soluble receptors comprising portions of both IL-17RC and IL-17RA ("IL-17RC/IL-17RA"). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. Also disclosed are methods of using such antagonists for treating disease, particularly inflammatory diseases mediated at least in part by IL-17A and/or IL-17F.

La présente invention concerne des antagonistes d'IL-17A et d'IL-17F. Lesdits antagonistes sont basés sur des protéines de fusion solubles IL-17RA et IL-17RC, incluant des récepteurs solubles hybrides qui comprennent des portions à la fois d'IL-17RC et d'IL-17RA (<= IL-17RC/IL-17RA >=). De tels antagonistes servent à bloquer, inhiber, réduire et contrer ou neutraliser l'activité de l'IL-17F, l'IL-17A ou à la fois de l'IL-17A et de l'IL-17F. La présente invention concerne également des procédés d'utilisation de ces antagonistes dans le traitement de maladies, en particulier de maladies inflammatoires induites au moins en partie par l'IL-17A et/ou l'IL-17F.

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