C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 38/58 (2006.01) C07H 21/00 (2006.01) C07K 14/81 (2006.01) C07K 14/815 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2164221
The present invention relates to novel inhibitors of human tryptase, to their isolation from leeches, to nucleotide sequences encoding the novel inhibitor molecules or fragments thereof, to vectors containing the coding sequence thereof, to host cells transformed with such vectors, to the recombinant production of the inhibitors, to pharmaceutical compositions containing the novel inhibitor molecules, and to their use in diagnosis and therapy.
L'invention porte sur de nouveaux inhibiteurs de la tryptase humaine, sur leur isolation à partir de sangsues, sur des séquences nucléotidiques codant pour de nouvelles molécules inhibitrices ou des fragments de celles-ci, sur des vecteurs comportant leur séquence de codage, sur les cellules hôtes transformées à l'aide desdits vecteurs, sur la production par recombinaison des inhibiteurs, sur des compositions pharmaceutiques contenant les nouvelles molécules inhibitrices et sur l'emploi desdites molécules à des fins diagnostiques ou thérapeutiques.
Fritz Hans
Sommerhoff Christian P.
Ag Ciba-Geigy
Fetherstonhaugh & Co.
Ucp Gen-Pharma Ag
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