A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/713 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01)
Patent
CA 2614110
The present invention features methods for treating or preventing conditions, diseases, or disorders related to oxidative stress. In one embodiment, the method increases Nrf2 biological activity or expression. In particular, the invention provides for the treatment or prevention of diseases relating to oxidative stress including emphysema, sepsis, septic shock, ischemic injury, cerebral ischemia and neurodegenerative disorders, meningitis, encephalitis, hemorrhage, cerebral ischemia, heart ischemia, cognitive deficits and neurodegenerative disorders.
L'invention concerne des procédés visant à traiter ou à prévenir des états pathologiques, des maladies ou des troubles associés au stress oxydatif. Dans un mode de réalisation, le procédé consiste à accroître l'activité biologique ou l'expression de Nrf2. L'invention permet en particulier de traiter ou de prévenir des maladies associées au stress oxydatif, y compris l'emphysème, la septicémie, le choc septique, les lésions ischémiques, l'ischémie cérébrale et les troubles neurodégénératifs, la méningite, l'encéphalite, l'hémorragie, l'ischémie cardiaque, les déficits cognitifs et les troubles neurodégénératifs.
Biswal Shyam
Dore Sylvain
Rangasamy Tirumalai
Sakata Yoshihito
Shah Zahoor Ahmad
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Johns Hopkins University
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