C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) C12N 1/38 (2006.01) C12N 9/04 (2006.01) C12P 7/40 (2006.01) C12P 7/44 (2006.01) C12P 7/46 (2006.01)
Patent
CA 2236472
A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability of catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants to grow. The invention also provides for a mutant that produces high amounts of succinic acid, which has been derived from a parent which lacked the genes for pyruvate formate lyase and lactate dehydrogenase, and which belongs to the E.coli Group of Bacteria.
La présente invention concerne un procédé d'isolement de bactéries produisant de l'acide succinique. Ce procédé consiste à accroître la biomasse d'un organisme dépourvu de l'aptitude à cataboliser le pyruvate puis à exposer à une atmosphère anaérobie la biomasse placée dans un milieu de culture riche en glucose de façon à permettre la croissance de mutants catabolisant le pyruvate. L'invention concerne également un mutant, produisant de grandes quantités d'acide succinique, dérivé d'un parent dépourvu des gènes de pyruvate formate lyase et de lactate déshydrogénase, et appartenant au groupe des bactéries E. coli.
Donnelly Mark
Millard Cynthia S.
Stols Lucy
Robic
The University Of Chicago
Uchicago Argonne Llc
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