Treatment of adverse effects associated with administration...

Details Treatment of adverse effects associated with administration... Treatment of adverse effects associated with administration...

A - Human Necessities

61

K

A61K 38/42 (2006.01) A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/44 (2006.01) A61K 31/4422 (2006.01) A61K 35/14 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2167716

The present invention relates to methods of lessening the severity and frequency of adverse effects associated with administration of extracellular hemoglobin comprising administration of a smooth muscle relaxant. Preferred smooth muscle relaxants are terbutaline and nifedipine, which can be administered in a prophylactic treatment, responsive regimented treatment or responsive intermittent treatment.

L'invention se rapporte à des procédés de diminution de la gravité et de la fréquence des effets indésirables associés à l'administration d'hémoglobine extracellulaire, lesdits procédés comprenant l'administration d'un dépresseur des fibres lisses. On peut citer des dépresseurs préférés des fibres lisses comme la terbutaline et la nifédipine, que l'on peut administrer à titre prophylactique, ou dans un traitement qui répond à un schéma posologique, ou encore dans un traitement qui répond de manière intermittente.

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