Antibiotic compounds

Details Antibiotic compounds Antibiotic compounds

C - Chemistry, Metallurgy

07

D

C07D 477/00 (2006.01) A61K 31/44 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 477/20 (2006.01) C07F 9/568 (2006.01)

Patent

CA 2099811

ABSTRACT ANTIBIOTIC COMPOUNDS The present invention relates to carbapenems and provides a compound of the formula (I) Image (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; and the pyridyl group is bonded to the nitrogen of the linking carbamoyl group by a carbon atom in either ring, is substituted with the carboxy group on a carbon atom, in either ring, and is optionally further substituted, on ring carbon atoms, by one or two substituents; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

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