Modulation of line-1 reverse transcriptase

Details Modulation of line-1 reverse transcriptase Modulation of line-1 reverse transcriptase

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/513 (2006.01) A61K 31/522 (2006.01) A61K 31/7072 (2006.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2553265

A reverse transcriptase encoded by L-1 (LINE-1) has been identified as a target molecule for treating or preventing cancers induced or mediated by this molecule. Method of treating or preventing such cancers in patients involves administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptase in cells of the patients. The inhibitor or antagonist blocks lengthening of telomeres in telomerase negative cells. Methods and kits for detecting pathologically proliferating cells expressing L1RT are also disclosed.

On a identifié une transcriptase inverse codée par L-1 (LINE-1) comme molécule cible pour le traitement ou la prophylaxie des cancers induits ou régulés par cette molécule. Le traitement ou la prophylaxie de ce type de cancer implique d'administrer aux malades une dose efficace sur le plan thérapeutique d'une composition comprenant un inhibiteur ou un antagoniste de la transcriptase inverse dans les cellules. L'inhibiteur ou l'antagoniste bloque le raccourcissement des télomères dans les cellules ne présentant pas d'activité de la télomérase. L'invention porte également sur des procédés et des trousses ou coffrets permettant de détecter des cellules dont la prolifération est pathologique et qui expriment la transcriptase inverse codée par rétrotransposon (L1RT).

Affiliated with

Also associated with

Rating

Modulation of line-1 reverse transcriptase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modulation of line-1 reverse transcriptase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modulation of line-1 reverse transcriptase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1442584