Diagnosis of migraine with aura, depression and anxiety from...

A - Human Necessities – 61 – K

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A61K 45/00 (2006.01) A61K 31/135 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2263149

The invention provides methods of diagnosing a syndrome characterized by symptoms of migraine with aura, depression and/or anxiety. Diagnosis entails detecting a variant form of one or more dopaminergic genes, such as DRD1, DRD2, DRD3 and DAT. Methods of screening for therapeutic agents effective to treat the syndrome and methods of treatment are also provided.

L'invention concerne des méthodes de diagnostic d'un syndrome caractérisé par des symptômes de migraine accompagnée d'aura, de dépression et/ou d'angoisse. Le diagnostic consiste à détecter un allèle d'au moins un gène dopaminergique, par ex. DRD1, DRD2, DRD3 et DAT. L'invention concerne également des méthodes de criblage d'agents thérapeutiques servant à traiter ledit syndrome, ainsi que des méthodes de traitement correspondantes.

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