Oral dosage form safeguarded against abuse containing (1r,...

Details Oral dosage form safeguarded against abuse containing (1r,... Oral dosage form safeguarded against abuse containing (1r,...

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2572352

The invention relates to an oral dosage form, which is safeguarded against abuse and which has a controlled release of (1R, 2R)-3-(3-dimethylamino-1- ethyl-2-methyl-propyl)-phenol for a once daily administering. The invention is characterized in that the oral dosage form comprises the active ingredient and/or one or more pharmaceutically acceptable compounds (A) thereof, at least one synthetic and/or natural polymer (C), retarding adjuvants, optionally comprises additional physiologically compatible adjuvants (B), and optionally comprises a wax (D). The oral dosage form has a breaking resistance of at least 500 N, preferably at least 750 N. The dosage form contains at least one of the following abuse-preventing constituents (a)-(f); (a) at least one substance that irritates the nasal and/or pharyngeal cavity; (b) at least one viscosity-increasing agent; (c) at least one antagonist for the active ingredient having an abuse potential; (d) at least one emetic; (e) at least one colorant serving as an aversive agent, and; (f) at least one bitter substance.

L'invention concerne une forme posologique anti-abus pour administration par voie orale, à libération contrôlée de (1R, 2R)-3-(3-diméthylamino-1-éthyl-2-méthyl-propyl)-phénol à administrer une fois par jour, qui se caractérise en ce qu'elle contient un principe actif et/ou au moins un composé (A) pharmaceutiquement acceptable de celui-ci, au moins un polymère (C) synthétique et/ou naturel, des adjuvants de retardement, éventuellement d'autres adjuvants (B) physiologiquement compatibles, et éventuellement une cire (D). Cette forme posologique présente une résistance à la rupture d'au moins 500 N, de préférence d'au moins 750 N. Elle contient au moins un des composants anti-abus suivants: (a) au moins une substance irritant le nez et/ou la gorge; (b) au moins un agent augmentant la viscosité; (c) au moins un antagoniste du principe actif présentant un certain potentiel d'abus; (d) au moins un émétique; (e) au moins un colorant en tant qu'agent répulsif; et (f) au moins une substance amère.

Affiliated with

Also associated with

Rating

Oral dosage form safeguarded against abuse containing (1r,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oral dosage form safeguarded against abuse containing (1r,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral dosage form safeguarded against abuse containing (1r,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1442633