Cryptic peptides for use in inducing immunologic tolerance

Details Cryptic peptides for use in inducing immunologic tolerance Cryptic peptides for use in inducing immunologic tolerance

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 39/35 (2006.01)

Patent

CA 2164326

Methods of inducing immunologic tolerance in a subject, such as human, by administering a tolerizing amount of a composition comprising a cryptic peptide derived from tbe antigen and a pharmaceutically carrier are described. Compositions which include a cryptic peptide derived from a protein antigen, such as an allergen or autoantigen, can be administered to induce tolerance in a naive or pre-sensitized individual. Preferably, the composition is administered orally.

On décrit des procédés qui permettent d'induire une tolérance immunologique chez un sujet tel que l'homme, grâce à l'administration d'une quantité, favorisant cette tolérance, d'une composition comprenant un peptide caché dérivé de l'antigène et un vecteur pharmaceutiquement acceptable. On peut administrer des compositions qui comportent un peptide caché dérivé d'un antigène protéique tel qu'un allergène ou un autoantigène, afin d'induire une tolérance chez un individu naïf ou présensibilisé. Cette composition s'administre de préférence par la voie orale.

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