C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2394015
The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
La présente invention concerne le récepteur TWEAK ainsi que des méthodes d'identification et d'utilisation d'agonistes et d'antagonistes du récepteur TWEAK. En particulier, l'invention concerne des méthodes de criblage d'agonistes et d'antagonistes et de traitement de maladies ou d'états induits par l'angiogénèse, tels que des tumeurs solides et des déficiences vasculaires des tissus cardiaques ou périphériques.
Immunex Corporation
Smart & Biggar
LandOfFree
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