A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 38/01 (2006.01) A61K 38/08 (2006.01) C07K 14/78 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2268029
The invention relates to the discovery, identification and use of laminin, laminin-derived protein fragments, and laminin-derived polypeptides, as well as related peptides and antibodies, for the therapeutic intervention and diagnosis of Alzheimer's disease and other amyloidoses. In addition, the discovery and identification of an Alzheimer's beta-amyloid protein specific binding within the globular domain repeats of the laminin A chain, had led to new diagnostic and therapeutic applications for Alzheimer's disease and other amyloidoses which are disclosed.
La présente invention concerne la découverte, l'identification et l'utilisation de la laminine, de fragments de protéine dérivée de la laminine et de polypeptides dérivés de la laminine, de même que des peptides et des anticorps correspondants permettant l'intervention thérapeutique et le diagnostic de la maladie d'Alzheimer et d'autres amyloses. En outre, la découverte et l'identification d'une protéine bêta-amyloïde spécifique, se liant dans des répétitions du domaine globulaire de la chaîne A de la laminine ont conduit à établir un nouveau diagnostic et de nouvelles applications thérapeutiques pour la maladie d'Alzheimer et d'autres amyloses qui font l'objet de cette invention.
Castillo Gerardo
Snow Alan D.
Smart & Biggar
University Of Washington
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