Treatment of cancer using benzoic acid derivatives

Details Treatment of cancer using benzoic acid derivatives Treatment of cancer using benzoic acid derivatives

A - Human Necessities

61

K

A61K 31/196 (2006.01) A61P 35/00 (2006.01) C07C 229/60 (2006.01)

Patent

CA 2553248

The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are methods of screening for benzoic derivatives based on their ability to inhibit the enzyme tyrosinase or to bind to and activate PXR/SXR xenobiotic receptors.

L'invention concerne une méthode de traitement du cancer faisant appel à des dérivés d'acide benzoïque, seuls ou combinés à des traitements standard, notamment une chimiothérapie et une radiothérapie. L'invention concerne également des méthodes de criblage de dérivés benzoïques, fondées sur la capacité de ces dérivés à inhiber l'enzyme tyrosinase ou à se lier à des récepteurs xénobiotiques PXR/SXR et à les activer.

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