Syntheses and preparations of narwedine and related novel...

Details Syntheses and preparations of narwedine and related novel... Syntheses and preparations of narwedine and related novel...

C - Chemistry, Metallurgy

07

D

C07D 491/10 (2006.01)

Patent

CA 2607811

The present invention relates to a process for preparing racemic narwedine (which can be can be kinetically resolved to yield (-)-narwedine and which is the biogenic precursor of (-)- galanthamine) and the use thereof as a starting material for producing (-)-galanthamine. The invention further includes processes for preparing (-)-galanthamine and (-)-galanthamine hydrobromide, as well as related novel compounds.

La présente invention concerne un procédé de préparation de narwédine racémique (pouvant être également résolue de manière cinétique pour obtenir la (-)-narwédine et constituant le précurseur biogénique de la (-)- galanthamine), et l'utilisation de celle-ci en tant que matière de départ pour produire la (-)-galanthamine. L'invention concerne également des procédés de préparation de (-)-galanthamine et d'(-)-hydrobromure de galanthamine, ainsi que de nouveaux composés associés.

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