C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) C12N 15/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2453939
A method is described for the identification of specific tumour antigens by means of the selection of CND display libraries by using sera, characterised in that said selection is accomplished with the phage display technique, and in particular said selection is accomplished by means of the SEREX technique (serological analysis of autologous tumor antigens through the expression of recombinant cDNA). The method according to the invention described herein advantageously combines the SEREX approach with the potency of the phage display technique defined above, at the same time avoiding the drawbacks characteristic of the SEREX technique. The so identified antigens are useful for the preparation of medicaments for the treatment of tumors.
L'invention concerne un procédé d'identification d'antigènes tumoraux spécifiques par sélection de banques d'expression d'ADNc au moyen de sérum. Ce procédé est caractérisé en ce que ladite sélection est effectuée au moyen de la technique d'expression phagique et notamment au moyen de la technique SEREX (analyse sérologique d'antigènes tumoraux autologues via l'expression d'ADNc recombinant). Le procédé selon l'invention combine, de manière avantageuse, l'approche SEREX avec les capacités de la technique d'expression phagique définie ci-dessus, tout en contournant les caractéristiques désavantageuses de la technique SEREX. Les antigènes ainsi identifiés sont utiles pour la préparation de médicaments destinés au traitement de tumeurs.
Felici Franco
Minenkova Olga
Fetherstonhaugh & Co.
Kenton S.r.l.
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