Antibacterial quinoline derivatives

Details Antibacterial quinoline derivatives Antibacterial quinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/435 (2006.01) A61P 31/00 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 405/06 (2006.01) C07D 405/10 (2006.01) C07D 409/10 (2006.01)

Patent

CA 2668517

The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or composit ions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.

La présente invention porte sur de nouveaux dérivés de quinoléine substitués selon la Formule générale (Ia) ou la Formule générale (Ib): comprenant n'importe quelle forme stéréochimiquement isomère de ceux-ci, un N-oxyde de ceux-ci, un sel pharmaceutiquement acceptable de ceux-ci ou un solvate de ceux-ci. Les composés revendiqués sont utiles pour le traitement d'une infection bactérienne. L'invention concerne également une composition comprenant un support pharmaceutiquement efficace et, en tant qu'ingrédient actif, une quantité thérapeutiquement acceptable des composés revendiqués, l'utilisation des composés revendiqués ou des compositions revendiquées pour la fabrication d'un médicament pour le traitement d'une infection bactérienne, et un procédé pour la préparation des composés revendiqués.

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